Anencephaly or aprosencephaly with an open skull is a defect of the central nervous system, this defect occurs at birth. It is serious because the baby is born with a large absence of a part of the brain and skull. It is a type of neural tube defect (NTD) and in the fusion of several neuronal tube closure sites.
Anencephaly causes a large part of the brain to come out of the skull, as seen in the image above.
Although the cerebral hemispheres can develop under this condition, any exposed brain tissue is subsequently destroyed. Due to these severe abnormalities, the base of the skull and facial bones do not show an average development, the frontal bone is almost always absent and the brain tissue is abnormal
Props to Best Gore member @nomar for the photo.
Still waiting on those Caption Photo Contest results 😉 Nice suggestion, though.